师资队伍
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朱璧然 教授

发布时间:2023-09-28 点击量:

职称 教授

学位 理学博士

邮箱 zhubir(at)hotmail.com (发邮件时请将(at)换成@)

主要招生专业及方向

中西医结合基础●生物技术在中医药研究中的应用

教育经历

2012.09–2015.07,中国科学院水生生物研究所,理学博士

主要工作经历

2024.01–至今,湖北中医药大学基础医学院,教授

2020.11–2023.12,湖北中医药大学基础医学院,副教授

2019.07–2020.01,夏威夷大学马诺阿分校公共卫生学院,访问学者

2018.11–2018.12,加州大学洛杉矶分校东西医学结合中心,访问学者

2016.09–2020.10,湖北中医药大学基础医学院,讲师

科研方向

1、环境中典型/新环境污染物对生物体内分析系统、繁殖功能、神经系统、微生物群落及营养代谢等方面的毒性效应及作用机理研究。

2、基于经典中医理论,筛选有效中药单体,研究其对代谢、生殖等疾病的干预效果及调控机制。

学术兼职

1、湖北省环境卫生专业委员会委员

2、国际期刊Eco-Environmental & Health青年编委

主要科研成果

主持项目

1、国家自然科学基金,十溴二苯乙烷对斑马鱼的神经毒性与线粒体动力学失衡的关系研究(42207332),2023.01–2025.12,30万,在研,主持

2、中国博士后科学基金,氯硝柳胺对斑马鱼的脂代谢干扰效应与肝X受体介导的机制研究(2021M693343),2021.06–2023.06,8万元,结题,主持

3、湖北中医药大学“双一流”建设杰出青年基金,益气健脾中药对新溴代阻燃剂诱导脂代谢紊乱的干预作用(1005032112),2023.06–2025.12,30万元,在研,主持

4、湖北省自然科学基金青年项目,LXRα和SREBP-1途径在氯硝柳胺引起斑马鱼脂代谢紊乱过程中的调控机制研究(2020CFB154),2020.03–2022.03,5万元,结题,主持

5、湖北省卫生健康委员会,灭螺药氯硝柳胺对斑马鱼幼鱼神经内分泌系统毒性影响和作用机制研究(WJ2019X006),2019.01–2020.12,2万元,结题,主持

6、湖北省教育厅,纳米二氧化硅和四溴双酚 A 复合暴露对斑马鱼幼鱼神经内分泌系统的影响及作用机制研究(Q20192010),2019.01–2020.12,2万元,结题,主持

代表性论著(#共同第一作者,*通讯作者

1、Lihua Yang, Biran Zhu*, Shanqi Zhou, et al. Mitochondrial dysfunction was involved in decabromodiphenyl ethane-induced glucolipid metabolism disorders and neurotoxicity in zebrafish larvae. Environmental Science & Technology, 2023, 57(30): 11043-11055. (SCI影响因子11.375,排名Q1)

2、Biran Zhu, Lei Lei, Yumiao Sun, et al. Niclosamide exposure at environmentally relevant concentrations efficaciously inhibited the growth and disturbed the liver-gut axis of adult male zebrafish. Environmental Science & Technology, 2022, 56: 11516-11526. (SCI影响因子11.375,排名Q1)

3、Biran Zhu, Lei Lei, Kaiyu Fu, et al. Neurotoxicity of tetrabromobisphenol A and SiO2 nanoparticle co-exposure in zebrafish and barrier function of the embryonic chorion. Science of the Total Environment, 2022, 845: 157364. (SCI影响因子10.753,排名Q1)

4、Biran Zhu, Ziniu Wang, Lei Lei, et al. Transcriptome reveals overview of Ca2+ dose-dependent metabolism disorders in zebrafish larvae after Cd2+ exposure. Journal of Environmental Sciences, 2023, 125: 480-491. (SCI影响因子6.795,排名Q1)

5、Biran Zhu*, Jian Han, Lei Lei, et al. Effects of SiO2 nanoparticles on the uptake of tetrabromobisphenol A and its impact on the thyroid endocrine system in zebrafish larvae. Ecotoxicology and Environmental Safety, 2021, 209: 111845. (SCI影响因子7.129,排名Q1)

6、Biran Zhu*, Wei He, Fan Yang, et al. High-throughput transcriptome sequencing reveals the developmental toxicity mechanisms of niclosamide in zebrafish embryo. Chemosphere, 2020, 244: 125468. (SCI影响因子8.943,排名Q1)

7、Biran Zhu*, Wei He, Shengchao Hu, et al. The fate and oxidative stress of different sized SiO2 nanoparticles in zebrafish (Danio rerio) larvae. Chemosphere, 2019, 225: 705-712. (SCI影响因子8.943,排名Q1)

8、Biran Zhu, Gang Zhao, Lihua Yang, et al. Tetrabromobisphenol A caused neurodevelopmental toxicity via disrupting thyroid hormones in zebrafish larvae. Chemosphere, 2018, 197: 353–361. (SCI影响因子8.943,排名Q1)

9、Biran Zhu, Qiangwei Wang, Yongyong Guo, et al. Effect of co-exposure to lead and decabromodiphenyl ether (BDE-209) on neurodevelopment in zebrafish larvae. Chemosphere, 2016, 144: 1646–1654. (SCI影响因子8.943,排名Q1)

10、Biran Zhu, Qiangwei Wang, Xiangfeng Wang, et al. Impact of co-exposure with lead and decabromodiphenyl ether (BDE-209) on thyroid function in zebrafish larvae. Aquatic Toxicology, 2014, 157: 186–195. (SCI影响因子5.202,排名Q1)

11、朱璧然*,李博,冯秋珍,等. 氯硝柳胺对斑马鱼幼鱼的神经毒性究. 中国寄生虫学与寄生虫病杂志, 2019, 37(5): 1–5. (北大核心;CSCD)

12、朱璧然*,李博. 氯硝柳胺对斑马鱼幼鱼甲状腺内分泌系统的影响. 中国血吸虫病防治杂志,2020, 32(1): 78–82. (北大核心;CSCD)

13、朱立一,何伟,朱璧然*. 纳米二氧化硅和铅复合暴露对斑马鱼幼鱼甲状腺内分泌系统的毒性影响. 长江流域资源与环境, 2018, 11(27): 2588–2596. (北大核心;CSCD)

14、何伟,朱立一,朱璧然*. 灭螺药氯硝柳胺急性暴露对斑马鱼胚胎/幼鱼代谢能力影响. 长江流域资源与环境, 2020, 29(12): 2679–2685. (北大核心;CSCD)

15、Yumiao Sun, Biran Zhu, Siyuan Ling, et al. Decabromodiphenyl ethane mainly affected the muscle contraction and reproductive endocrine system in female adult zebrafish. Environmental Science & Technology, 2022, 56: 1470-1479. (SCI 影响因子11.375,排名Q1)

16、Lei Lei, Biran Zhu, Kun Qiao, et al. New evidence for neurobehavioral toxicity of deltamethrin at environmentally relevant levels in zebrafish. Science of the Total Environment, 2022, 822: 153623. (SCI 影响因子10.753,排名Q1)

17、Jianghuan Hua, Biran Zhu, Wei Guo, et al. Endocrine disrupting effects induced by levonorgestrel linked to altered DNA methylation in rare minnow (Gobiocypris rarus). Comparative Biochemistry and Physiology, Part C, 2022, 257:109332. (SCI影响因子4.520,排名Q2)

18、Lianguo Chen, Biran Zhu, Yongyong Guo, et al. High throughput transcriptome sequencing reveals the combined effects of key e-waste contaminants, decabromodiphenyl ether (BDE-209) and lead, in zebrafish larvae. Environmental Pollution, 2016, 214: 324-333. (SCI 影响因子9.988,排名Q1)

19、Wei Miao, Biran Zhu, Xiaohong Xiao, et al. Effects of titanium dioxide nanoparticles on lead bioconcentration and toxicity on thyroid endocrine system and neuronal development in zebrafish larvae. Aquatic Toxicology, 2015, 161: 117–126. (SCI 影响因子5.202,排名Q1)

20、Yumiao Sun, Shanqi Zhou, Biran Zhu, et al. Multi- and transgenerational developmental impairments are induced by decabromodiphenyl ethane (DBDPE) in zebrafish larvae. Environmental Science & Technology, 2023, 57: 2887-2897. (SCI影响因子11.375,排名Q1)

21、Xiaoxue Wu, Yundan Xu, Biran Zhu, et al. Resveratrol induces apoptosis in SGC-7901 gastric cancer cells. Oncology Letters, 2018, 16: 2949-2956. (SCI 影响因子3.111,排名Q3)

获奖及人才计划

1、2018年,湖北省青年科技晨光计划

2、2018年,基础医学院“优秀教师”

3、2020年,基础医学院青年教师教学竞赛“二等奖”

4、2023年,湖北中医药大学教学创新大赛“一等奖”

主讲课程(研究生,本科生)

医学细胞生物学、医学文献检索

备注